Beilstein J. Org. Chem.2014,10, 1840–1847, doi:10.3762/bjoc.10.194
of single modifications with nucleosides of the bicyclo-/tricyclo-DNA platform within deoxyoligonucleotides are not predictive for the stability of fully modified oligonucleotides.
Keywords: DNA/RNA affinity; nucleic acids; nucleosides; oligonucleotides; oligonucleotidetherapy; X-ray structures
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Graphical Abstract
Figure 1:
Chemical structures and carbon numbering scheme of tricyclo(tc)-DNA (top, left), bicyclo(bc)-DNA (t...